Background: Hailey-Hailey disease (HHD), also known as benign familial pemphigus, is a rare autosomal dominant genodermatosis characterized by recurrent vesicles, blisters, erosions, and maceration, predominantly involving intertriginous areas. It is associated with mutations in the ATP2C1 gene on chromosome 3q21–q24, resulting in impaired calcium homeostasis and defective keratinocyte adhesion. Heat, friction, sweating, and other physical stresses may precipitate or exacerbate lesions. Case Report: A 32-year-old female presented to the Dermatology Outpatient Department with a history of blisters. A skin/soft-tissue biopsy specimen was obtained and submitted for histopathological examination. Microscopy revealed stratified squamous epithelium showing prominent acantholysis at multiple levels, predominantly in the suprabasal region, producing the characteristic “dilapidated brick wall” appearance. The dermal papillae were elongated and lined by a single layer of basal cells. Occasional dyskeratotic cells/scales and mild mixed inflammatory cell infiltration were also observed in the subepithelial dermis. Based on the characteristic histopathological findings, a diagnosis of Hailey-Hailey disease was made. Conclusion: Hailey-Hailey disease is an uncommon, benign, chronic, and relapsing genodermatosis that may pose a diagnostic challenge because of its variable clinical presentation and resemblance to other blistering and erosive disorders. Recognition of the characteristic suprabasal acantholysis and dilapidated brick-wall appearance on histopathology is important for diagnosis. Awareness of this entity among clinicians and pathologists can facilitate early diagnosis and appropriate management.