Background: Clinical manifestations of haematological malignancies range from vague systemic signs to sudden multi-organ failure. The study was conducted to determine the prevalence and clinicopathological profile at a Tertiary Care Centre to better understand the nature of the disease and improve treatment outcomes. OBJECTIVES: The objectives of the research were to assess the clinical features and pathological profile and the distribution of various hematological malignancies. MATERIAL AND METHODS- This retrospective observational study included 158 cases with relevant clinical features and hematological findings in the Department of Medical Oncology of our tertiary care centre. This study period spanned two years, from January 2023 to December 2024. RESULTS- Most patients belong to the age group 51-60 years (22.8%). The average median age for diagnosis was 50 years. The number of males was more than females (53.8% vs 46.2%). The majority of them were unskilled workers, followed by semi-skilled workers. Fever (93%) was the most frequently reported symptom, while the pallor (95.4%) was the most common clinical sign. CONCLUSION- This retrospective study highlights the diverse clinicopathological spectrum of hematological malignancies encountered at a tertiary care centre. The findings underscore the presence of certain malignancies such as leukemia and lymphoma, with a noticeable variation in age distribution, gender prevalence, and clinical presentation. Early diagnosis based on hematological, histopathological, and immunophenotypic parameters is critical for timely and effective treatment planning. The study emphasizes the need for continuous surveillance, improved diagnostic infrastructure, and standardized treatment protocols to enhance patient outcomes. Further prospective studies with large sample size are required for better understanding of the evolving trends and to guide evidence-based clinical practice.