Original Article
Open Access
Study on Incidence and Clinical Profile of Anemia
Pages 66 - 70

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Abstract
Background: Aim: Study on incidence and clinical profile of anemia. Methods: This was a prospective observational study conducted in the Department of General Medicine, Santosh Medical College and Hospital, Ghaziabad, (U.P.), India from August 2017 to February 2018. In all 100 patients thorough history was taken, general physical examination and systemic examination were done. Patients were subjected to routine blood investigations including complete blood count, peripheral smear study and serology for viral markers. Results: 50 (50%) were easy fatiguability and generalised weakness the most common symptoms of anaemia in our study. Incidentally detected patients constituted 33% of patients and were the second most common in occurrence. This was followed by breathlessness seen in 21% of patients. Pallor was noted in all patients. Platonychia/koilonychia suggesting iron deficiency anaemia was seen in 28(28%) of patients, whereas knuckle pigmentation suggestive of megaloblastic anaemia was observed in 19(19%) of patients. 16 (16%) patients presented with anaemia in failure as evidenced by elevated jugular venous pulse and pedal oedema. None of the patients in this study was due to hemolysis. Hence icterus seen in 8(8%) patients was due to ineffective erythropoiesis seen in patients with megaloblastic anaemia. On systemic examination haemic murmurs on CVS examination were detected among 24(24%) patients. Bibasilar crepts not attributable to other diseases were found among 6 patients. Isolated hepatomegaly was found in 13(13%), splenomegaly in 8(8%) and hepatosplenomegaly was found in 8 patients. Whereas severe anaemia showed 86 (86%) highest occurrences. Microcytic hypochromic anaemia 48(48%) attributed to iron deficiency unless proved otherwise was the most common form of anaemia in our study. Dimorphic anaemia 28(28%) was the second most common suggesting that nutritional anaemia continues to predominate in our part of world. Conclusion: We conclude that some extensive steps taken by WHO and Government bodies in educating and treating people about the disease.
Research Article
Open Access
Histopathological study of neoplastic lesions of thyroid in a tertiary care teaching hospital.
Pages 62 - 65

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Abstract
Background: Aim: Histopathological study of neoplastic lesions of thyroid in a tertiary care teaching hospital. Methods: This study was carried out in the Department of Pathology, Rama Medical College, Hospital & Research Centre, Hapur, Uttar Pradesh, India, for 15 months. The material for this study consisted of thyroidectomy specimens including lobectomy, partial thyroidectomy, subtotal thyroidectomy and total thyroidectomy. Every patient was preoperatively assessed by FNAC. Detailed information regarding age, gender, clinical details (hypothyroid, hyperthyroid and euthyroid), relevant investigations like Fine Needle Aspiration Cytology, USG reports, thyroid scan and operative findings were obtained from histopathological report forms. Results: 80% cases were found to be females and 20% cases were males with a female: male ratio of 4:1. Among total of 100 neoplastic lesions, 27 cases were adenomas 21 cases of follicular adenoma and 6 cases of Hurthle cell adenoma were diagnosed accounting for 21% and 6% respectively of all neoplastic thyroid lesions. The age of the studied benign thyroid neoplastic lesions ranged from 11 years to 67 years with a mean age of 37.95 years and the relative peak age of incidence was seen in 20-30 years age group (28%). The young age group (≤20 years) and the elderly age group above 60 years constituted 9% and 5% of cases respectively. Malignant thyroid lesions accounted for 73% (n=73) of all neoplastic lesions. Papillary carcinoma was the commonest malignant tumor in this study seen in 60 (82.19%) of all malignant lesions. Of these cases, 10 (16.67%) were males and 50 (83.33%) were females with a female: male ratio 5:1. Most of the patients (n=18; 30%) were between 20-30 years of age. 8 cases of follicular carcinoma and 4 cases of medullary carcinoma were encountered in this study, comprising of 8% and 4% of all malignant neoplasms respectively. No case of anaplastic carcinoma was seen in our study. Conclusion: Thus, in conclusion, females accounted for 80% of patients with neoplastic thyroid lesions and the incidence peaked at a younger age. Papillary carcinoma was the most frequent thyroid cancer accounting for 60% of thyroid cancers and follicular adenoma was the common benign tumor.
Research Article
Open Access
Pattern and Determinants of Ocular Morbidity among Senior Citizens Attending a Tertiary Care Hospital in India”
Pages 54 - 61

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Abstract
Background: Ocular morbidity is a significant public health problem among the geriatric population in India. With increasing life expectancy, age-related eye disorders are becoming more prevalent, leading to visual impairment and reduced quality of life. The frequency of eye diseases has been suggested to start increasing around 40 years of age, with an even steeper increase beginning around 60 years of age. Health promotions and curative and rehabilitative services for the visually impaired elderly population should therefore be a priority in the coming years especially in low and middle income countries. Aim: To study the pattern and determinants of ocular morbidity among senior citizens attending a tertiary care hospital. Materials and Methods: A team from the Department of Ophthalmology conducted house visits and did a complete eye examination of 450 elderly subjects. They were selected by systematic random sampling from the data base available in the Department of Ophthalmology. Results: A total of 900 eyes were examined. Visual impairment and blindness was seen in 135 (30%) and 36 (8%) individuals respectively. The most common cause of blindness was cataract, followed by corneal opacity, glaucoma, refractive error, diabetic retinopathy, macular scar, age related macular degeneration, retinal detachment, retinitis pigmentosa. Visual impairment was more in individuals with low socioeconomic status. Conclusion: The results of this study suggest that though cataract remains the main cause of blindness, there is an increase in blindness and visual impairment due to corneal diseases and glaucoma which was not seen earlier. The availability and accessibility to eye care facilities particularly for corneal diseases and glaucoma should be increased to reduce blindness in Northern India.
Research Article
Open Access
Prevalence and Risk Factors of Dry Eye Disease A Cross-Sectional Study in a Tertiary Care Teaching Hospital
Pages 48 - 53

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Abstract
Background: Dry eye disease (DED) is one of the most prevalent eye conditions affecting millions of people. It is also known as tear film dysfunction and one of the most common ocular disorders affecting the general population. It can cause disabilities ranging from mild irritation to severe debilitation due to loss of homeostasis of the tear film. Tear film is a 3-layered structure of mucin, aqueous and lipid layer. Material & methods: The study was conducted from 20/01/2017 to 31/12/2017 for one year. The entire rural population of specific area (block wise) having 272500 persons were contacted. 76196 persons were found symptomatic and were subjected to standard Shirmer’s test without anesthesia in field area. The data was recorded separately for age and sex groups. The DED determination was done on the basis of positive Shirmer’s test reading less than 10 mm. There were three age groups 0 to 25 years, 25 to 50 years and more than 50 years. Male and female were recorded separately. Results: Prevalence of DED in females 0-25 year group 5.5%, 25-50 years 15.1% and more than 50 years 57.01%. Males had 0-25 years group 4.1%, 25-50 years 15.9% while more than 50 years 65.1%. Overall prevalence for 0-25 years 4.77%, 25-50 years 15.5% and more than 50 years was 60.87%. The DED prevalence in rural population was determined 19.2% which is in the same order with previous studies. Conclusion: However more resources required conducting other diagnostic test for DED in field settings, then the prevalence may be more in rural population as accepted theoretically.
Research Article
Open Access
PREVALENCE OF GENERALIZED ANXIETY DISORDER AMONG MBBS STUDENTS IN CHENNAI MEDICAL COLLEGES: A CROSS-SECTIONAL STUDY
Arunkumar Shanmugasundaram ,
Hanitha Rajasekar
Pages 41 - 47

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Abstract
Background: Medical education is highly stressful, with students facing rigorous curriculum, extensive study hours, and clinical responsibilities. Generalized Anxiety Disorder affects 18-45 % of medical students globally, substantially higher than the general population prevalence of 3.1 %. In India, specific data on GAD using validated instruments remains limited, particularly regarding clinical posting stress and academic performance impacts. Objective: To determine the prevalence of Generalized Anxiety Disorder among MBBS students in Chennai medical colleges, compare anxiety levels across different academic years, and correlate GAD with examination performance and clinical posting stress. Methods: A cross-sectional study was conducted among 450 MBBS students from four medical colleges in Chennai during January to March 2018. GAD was assessed using the validated GAD-7 scale. Data on demographics, academic performance, clinical posting stress, and lifestyle factors were collected. Statistical analysis included chi-square test, t-test, ANOVA, Pearson correlation, and multiple logistic regression. Results: Overall GAD prevalence was 42.7 %. Female students showed higher prevalence (48.5 % vs 34.6 %, p=0.003). GAD increased across academic years, peaking at Third year Part-II (56.8 %, p<0.001). Significant negative correlation existed between GAD-7 scores and examination performance (r=-0.456, p<0.001). Among clinical students, 71.4 % reported clinical posting stress, strongly associated with GAD (OR=3.12, p<0.001). Independent predictors included female gender (OR=1.86), clinical years (OR=2.34), academic failure (OR=2.91), clinical stress (OR=3.12), and poor sleep (OR=2.28). Only 23.4 % sought professional help. Conclusion: GAD prevalence among MBBS students is alarmingly high, particularly during clinical years. The strong association with academic performance and clinical posting stress necessitates comprehensive mental health support programs in medical colleges.
Research Article
Open Access
Gestational Diabetes: Risk Factors, Diagnosis and Treatment
Tashin Mushtaque,
Vaibhavibahen Divyesh Kumar Patel
Pages 33 - 40

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Abstract
Objective: The objective of this study was to investigate the prevalence, risk factors, diagnostic approaches, treatment strategies, and associated complications of gestational diabetes mellitus (GDM). Methodology: This study employed a cross-sectional observational design conducted in a clinical setting. The population consisted of pregnant women aged 18 and above, attending antenatal clinics in healthcare facilities. A total of 300 participants were selected using purposive sampling. The inclusion criteria included pregnant women between 24 and 28 weeks of gestation with no prior history of type 1 or type 2 diabetes. Data were collected through structured interviews, medical record reviews, and laboratory tests, including blood glucose measurements and oral glucose tolerance tests. Descriptive and inferential statistical methods were used for data analysis. Results: The study found that the prevalence of gestational diabetes was higher in women over the age of 35, women with obesity, and those with a family history of diabetes. Ethnic disparities were observed, with Hispanic women showing the highest prevalence of GDM. Insulin therapy was identified as the most effective treatment, with 90% of women achieving blood glucose control. Lifestyle interventions, such as diet control and exercise, were also beneficial, although slightly less effective than insulin therapy. The study also identified common complications of GDM, including macrosomia, neonatal hypoglycaemia, and an increased likelihood of caesarean sections. Conclusion: The study concluded that gestational diabetes is a significant health concern with profound implications for both maternal and fetal health. Early screening, targeted interventions, and a multidisciplinary approach to treatment are crucial in managing the condition and preventing complications. The findings underscore the importance of addressing risk factors such as obesity, age, and ethnicity in the prevention and management of GDM. Further research is needed to explore the long-term outcomes for both mothers and their children.
Case Report
Open Access
Surgical management of bilateral gigantic pubertal gynecomastia – a case report
Cristian Nițescu,
Bogdan Nițescu,
* Andrada Despina Munteanu
Pages 28 - 32

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Abstract
Introduction The article is a case report of a young (14-year-old) patient with gigantic bilateral idiopathic gynecomastia, whom we operated on, in order to restore the local anatomy. Case report A boy was referred to our unit, and was admitted for surgical treatment of bilateral gynecomastia. We couldn’t find any pertinent cause, after all blood tests were normal, after an endocrinological exam, which showed no problems concerning the hormone levels, and after finding no drugs or other genetic factors in the history of the patient. The excess of skin, fatty tissue, as well as mammary tissue, made any other more conservative treatment pointless and non-effective. That is why we performed surgery, using a method that is a combination between the classical gynecomastia approach and the breast reduction "inverted T” one, personalized for this case. Conclusion The results were good, despite some minor scarring issues, which we handled promptly. We thought this is a valuable case so we presented it thoroughly, because few gynecomastia patients have important enlargement of the breast region and there is scarce data about this particular issue.
Case Report
Open Access
Non-Hodgkin lymphoma of the upper right eyelid – a case report
Cristian Nițescu,
Bogdan Nițescu,
* ,
Andrada Despina Munteanu
Pages 22 - 27

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Abstract
Introduction The present paper is a report about an interesting case of a tumoral mass situated in the upper eyelid of the right eye, which was actually a cutaneous form of non-Hodgkin lymphoma. Case report The tumor had been operated in another unit several times and had recurred, the patient having undergone surgery in other areas as well for removal of the same type of masses. The patient came to our unit because he was bothered by the abnormal growth in his eyelid, which limited his blinking movements and his visual field. Surgery was the only effective treatment, so we performed a wavy incision and tried to remove the entire tumoral mass, which was situated between the muscle fibers, very carefully, maintaining both function and aesthetic appearance. After surgery we had the patient come for several periodical check-ups, so we could rest assured that he healed beautifully and had no functional impairment. Conclusion The pathology analysis of the excised mass confirmed that it was a non-Hodgkin lymphoma. The results were very good and the patient was pleased to be able to have a wider, normal vision area. When doing our research we noticed that there are few cases of this type described in plastic surgery literature, so we presented this case, underlining the essential steps in preoperative assessment, surgical technique and postoperative conduct, in hope that the information will be useful for colleagues from the medical field.
Case Report
Open Access
Rare anatomic variation: anastomosis of the superficial epigastric and superficial circumflex iliac arteries
Bogdan A Manta,
Mugurel Constantin Rusu,
*
Pages 18 - 21

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Abstract
Introduction The superficial (inferior) epigastric artery (SEA, SIEA), as well as the superficial circumflex iliac artery (SCIA), are superficial branches of the femoral artery. They supply various flaps used in reconstructive surgery, thus their potential anatomic variation is important. Case report We hereby report a previously unknown anatomic variant, the anastomosis of the SEA and SCIA. This was found serendipitously during a cadaveric dissection, within the left femoral triangle, within the subcutaneous tissue below the inguinal ligament. Although it was mostly located above the saphenofemoral junction, the insertion into the SEA was placed immediately beneath the femoral end of the greater saphenous vein. The SEA-SCIA anastomosis appeared mostly as a supplier of the superficial inguinal lymph nodes. Conclusion Such an anatomical variant is of interest not only for surgeons harvesting SEA and/or SCIA flaps, but also during surgery of the saphenofemoral junction.
Case Report
Open Access
Schwannoma of the left ulnar nerve – a case report
Cristian Nițescu,
Bogdan Nițescu,
* ,
Andrada Despina Munteanu
Pages 13 - 17

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Abstract
Introduction The present paper is a case report about an interesting case of schwannoma, one of the most common benign, but discomfort-producing nerve tumors. Case report We present the case of a 54-year-old female patient, with a tumor located in the upper third of the left forearm, more precisely, in the ulnar nerve, causing paresthesia in the fourth and fifth fingers, as well as pain when touching the affected area. The patient was referred to our unit by a rheumatologist and came with an MRI and an electromyogram, which provided us helpful guidance to the potential diagnosis. Surgery was the only effective treatment, therefore we performed enucleation of the schwannoma and primary repair of the nerve. After the procedure we had the patient come for check-ups, so we could conclude that the nerve fully recovered. Conclusion The results were very good and the patient was pleased with the outcome. As suspected, the pathology analysis of the excised tissue confirmed that the tumor was a schwannoma. We accurately presented this case in detail, pointing out the essential preoperative aspects, as well as the surgical technique and postoperative conduct, in order to help younger colleagues or people from other fields of medicine set the right diagnosis and treat correctly the patients with nerve tumors.
Research Article
Open Access
Comparative analysis of tigecycline and minocycline susceptibility among Gram-negative isolates
Vidya Devarajan,
Nitin Bansal,
* ,
K Abdul Ghafur
Pages 8 - 12

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Abstract
Introduction Limited options are available for the treatment of infections caused by carbapenem-resistant Gram-negative organisms (CR-GNB). Tigecycline is one of the alternatives to treat these CR-GNB infections but it has limitations due to its pharmacokinetic/pharmacodynamic (PK/PD) characteristics, whereas minocycline is reported to have a superior PK/PD profile compared to tigecycline. MethodsThis is a retrospective analysis of in vitro susceptibilities to minocycline and tigecycline in Acinetobacter and Enterobacteriaceae isolates from various sites including blood, urine, and tissue between January 2014 and April 2015 from a tertiary care oncology, bone marrow transplant and neurosurgical center in South India. Identification of isolates and antibiotic susceptibility testing was done using Vitek 2, using CLSI 2014 breakpoints. Results A total of 1101 Gram-negative isolates were analyzed (Acinetobacter– 161, E. coli – 825, Klebsiella – 115). Out of these, carbapenem-resistant (CR) isolates were Acinetobacter– 122, E. coli – 107 and Klebsiella – 50. Among CR Acinetobacter, E. coli and Klebsiellaisolates, tigecycline susceptibility was 64.75%, 98.13% and 34% respectively and minocycline susceptibility was 66.39%, 26.16% and 8% respectively. Conclusion Acinetobacterisolates, including carbapenem resistant ones showed comparable susceptibility for both minocycline and tigecycline. Hence minocycline may be an attractive alternative to treat CR Acinetobacter infections.
Editorial
Open Access
Esthetic Connections – the 15th International Congress of Esthetic Dentistry in Bucharest, Romania
Pages 6 - 7

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Abstract
Reaching this year its 15thedition, the International Congress of Esthetic Dentistry (ICED) has become a reference event in Romania and the neighboring countries. While in the last years the number of medical scientific events has increased greatly, one has to carefully assess the program, speaker lineup and topics discussed in each announced event, because it has become impossible to attend all of them. This is not the case with the yearly Congress of Esthetic Dentistry, since the past editions have clearly made this event one of the few "must go” congresses for Romanian dentists and dental technicians.